Clayton Merrell grew up in Pittsburgh, PA, and Ciudad Guayana, Venezuela. He studied painting and printmaking at the Yale School of Art, where he earned an MFA in 1995. He was awarded a Fulbright for research and creative work in Oaxaca, Mexico in 1996-1997. His work is exhibited widely at venues including: the Smithsonian National Air and Space Museum, Washington, DC; Concept Art Gallery, Pittsburgh, Pennsylvania; the A+D Gallery, Chicago, Illinois; the Westmoreland Museum of Art; and the Chautauqua Institution, Chautauqua, New York. His work is in the collections of the American Embassy in Belmopan, Belize, the Smithsonian Museum, the Anderson Museum of Contemporary Art, the US Department of the Interior, and numerous private and corporate collections. He was the 2005 Artist of the Year at The Pittsburgh Center for the Arts, and in 2016 was named Creator-of-the-Year by the Pittsburgh Technology Council. He has received awards and fellowships from MASS MoCA, the Heinz Foundation, Virginia Center for the Creative Arts, Skowhegan School of Painting & Sculpture, Blue Mountain Center, Vermont Studio Center, ProArts, Artists Image Resource, and Center for the Arts in Society. During 2004–2005 he was a fellow at the Roswell Artist-In-Residence Foundation in Roswell, New Mexico. In 2015, the Pittsburgh International Airport completed construction of a 69,000 square foot terrazzo floor based on his design. He has been commissioned to expand on that design as part of the Terminal Modernization Project now under construction. He is currently the Dorothy L. Stubnitz Professor of Art at Carnegie Mellon University.